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Iatrogenic and occupational prion transmission of human prion diseases has occurred. While methods of prion surface decontamination exist, validating that decontamination procedure are successful is currently not possible. This proposal will utilize an innovative surface-recovery method combined with real-time quaking-induced conversion (RT-QuIC) to detect residual prions from a variety of surfaces. The results of these studies will allow for surveying of residual prions in laboratory and clinical settings.
About the Researchers:
Jason C. Bartz, Ph.D. and Dr. Yuan, Ph.D.
School of Medicine, Creighton University, Omaha NE
Detection of residual prions from decontaminated medical and laboratory surfaces
Dr. Yuan is a Research Assistant Professor in the Department of Medical Microbiology and Immunology at the Creighton University School of Medicine. Dr. Yuan earned a Ph.D. in Civil engineering at the University of Nebraska, Lincoln. Dr. Yuan investigates environmental prion fate and has identified important factors affecting its persistence and has developed a novel methodology to detect surface prions that has utility in environmental, laboratory, and medical settings.
Dr. Bartz is Professor and Chair in the Department of Medical Microbiology and Immunology at the Creighton University School of Medicine. Dr. Bartz earned a Ph.D. at the University of Wisconsin, Madison. Dr. Bartz investigates interspecies transmission, pathogenesis, and the biology of prion strains whose work has sought to understand how a protein-only infectious agent can perform complex biological tasks.
Recipient Of:
- The Peggy J. Black Memorial Grant, contributed by Jim Black and Family
- The Tom Stivison Memorial Research Grant, contributed by Sandra (Cookie) Stivison
- The Strides for CJD Research Grant, contributed by the families of the CJD Foundation
- The CJD Foundation Grant, contributed by the families of the CJD Foundation
- The Rudy Wolter Memorial Grant, contributed by Amanda Wolter and Family