Roberto Chiesa, PhD
Grant Title:
“Nanoparticle-mediated brain delivery of a tetracationic porphyrin with potent anti-prion activities”
Location:
Laboratory of Prion Neurobiology, Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
Grant Year:
2019
Downloads:
Dr. Chiesa has identified a porphyrin that has two potentially synergic anti-prion properties: it down-regulates PrPC, thus depleting the substrate for prion formation, and inhibits PrPSc replication in in vitro and ex vivo models. The aims of the project are: 1) to use nanoparticles engineered to cross the blood-brain barrier to efficiently deliver this compound to the brain; and 2) to carry out efficacy tests in prion-infected mice.
To learn more about Dr. Chiesa's previous CJD Foundation Research Grant, click here.
Dr. Chiesa is the recipient of:
- The Cheryl Molloy Memorial Grant, contributed by Tim Molloy and Family