Zerui Wang, MD, PhD and Katsumi Doh-ura, MD, PhD

Grant Title:

"Assessing Prophylactic and Therapeutic Efficacy of a Cellulose Ether Compound TC-5RW on CJD"

Location:

Department of Pathology, Case Western Reserve University, Cleveland, Ohio

Grant Year:

2022

So far there has been no cure for the fatal transmissible human prion diseases including the most common sporadic Creutzfeldt-Jakob disease (sCJD) that are characterized by the deposition of a misshaped infectious prion protein called (PrPSc) in the brain.

TC-5RW is a compound of cellulose ethers (CEs) that have already widely been used as inactive ingredients in foods and pharmaceuticals. Interestingly, our recent study has revealed for the first time that TC-5RW is able to directly decrease the amount of human PrPSc and inhibit PrPSc seeding activity in tissues from various sporadic and genetic CJD in vitro.

Therefore, it is most likely that CEs can be used for clinical trials of human prion diseases. For example, CEs may have a prophylactic effect on asymptomatic carriers of PrP mutations that are associated with various genetic prion diseases. Most of the asymptomatic PrP mutation carriers inevitably develop genetic prion diseases during aging.

In collaboration with Dr. Qingzhong Kong from Case Western Reserve University, Cleveland, Ohio, USA, and Dr. Ruth Gabizon, from Hadassah University Hospital, Jerusalem, Israel, this proposed study will test the efficacy of CE compound TC-5RW in the prevention and treatment of prion diseases with animal models that express human PrP infected with the most common subtype of sporadic CJD and an animal model of genetic CJD that develops prion disease spontaneously. This study is highly relevant to human prion diseases, especially to developing efficient prophylactic and therapeutic compounds for CJD.

About the Researchers:

Zerui Wang, MD, PhD
Department of Pathology, Case Western Reserve University, Cleveland, Ohio

Dr. Zerui Wang is an Assistant Professor from the Department of Pathology, at Case Western Reserve University School of Medicine, Cleveland, Ohio.

Dr. Wang received her medical degree and Ph.D. from Jilin University, China. She accomplished a joint Ph.D. program and pursued post-doctoral studies at the Institute of Pathology, Case Western Reserve University, Cleveland, Ohio. Her scholarly emphasis during this period was on prion diseases and prion-like neurodegenerative ailments.

Dr. Wang’s research work mainly lies in the early detection methodologies for prion disease and other neurodegenerative diseases, including Alzheimer's and Parkinson's. She strives to diagnose these diseases from peripheral tissue and bodily fluids, with a particular interest in distinguishing among prionopathies, synucleinopathies, and tauopathies using seeding models.

Currently, Dr. Wang is Dr. Wang is developing both preventive and curative compounds targeting prion diseases and other neurodegenerative disorders.

Katsumi Doh-ura, MD, PhD
Professor, Department of Neurochemistry, Tohoku University Graduate School of Medicine, Japan

Dr. Doh-ura studied neuropathology and genetics of human prion diseases when he was a graduate student of Jun Tateishi’s lab in Kyushu University, Japan, from 1987 to 1991. Thereafter, he worked as a postdoc at Bruce Chesebro’s lab in NIAID/NIH, USA, till 1994. He started the research on prion therapeutics when he obtained a position at Kyushu University in 1995. He joined Tohoku University as a faculty member in 2003, where he has continued his research on prion therapeutics.

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