Steven E. Arnold, MD
Grant Title:
“Assessing long-term stability of cerebrospinal fluid PrP levels in genetic prion disease mutation carriers”
Location:
Professor of Neurology, Harvard Medical School; and Translational Neurology Head of the Interdisciplinary Brain Center, Massachusetts General Hospital
Grant Year:
2019
Downloads:
Prion disease can only happen if the brain produces PrP, the protein that misfolds to cause the disease. Drugs are being developed to lower the amount of PrP in the brain which will prevent or stop the disease. To establish the efficacy of those drugs, it is necessary to measure PrP in spinal fluid in order to figure out whether it was reduced. The investigators have been collecting spinal fluid from people at risk for genetic prion disease to answer this question, and the new grant from CJD Foundation will enable the team to extend the timeline of the study and look at long-term stability in PrP measurements in spinal fluid over more than one year.
Dr. Arnold is the recipient of:
- The Michael H. Cole Memorial Grant, contributed by Jeanne Cole
- The Cheryl Molloy Memorial Grant, contributed by Tim Molloy and Family
- The José A. Piriz and Sonia E. Piriz Memorial Grant, contributed by Karla Piriz and Lauren Piriz
- The Jeffrey A. Smith Memorial Grant, contributed by The Jeffrey and Mary Smith Family Foundation
- The Mercies in Disguise Memorial Grant, contributed by Kathy Baxley and Family