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1-26-24: Clinical Trial Announcement

1-26-24 Clinical Trial Announcement: Multiple Sites Now Open In and Outside the U.S. To learn about additional sites that have opened: Information on ION717 Clinical Trial 10-4-23 Community Statement from Ionis Pharmaceuticals 12-21-23 Clinical Trial Announcement from Ionis Pharmaceuticals

Gerold Schmitt-Ulms, PhD

Grant Title:
Bridging the pre-clinical gap for a small brain-penetrant molecule that reduces PrPC levels

Location:
Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto

Grant Year: 2024

Debbie McKenzie, PhD

Grant Title:
Modulation of Toll-Like Receptor Signaling: Unveiling Neuroinflammation and Therapeutic Strategies in Creutzfeldt-Jakob Disease

Location:
University of Alberta

Grant Year: 2024

Dr. Surabhi Mehra

Grant Title:
Understanding the molecular mechanism of spontaneous prion emergence in knock-in mouse models

Location:
Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto

Grant Year: 2024

Arielle Hay, Ph.D.

Grant Title:
Generating cerebral organoids from donors with sporadic Creutzfeldt-Jakob Disease

Location:
Postdoctoral Research Fellow at Rocky Mountain Laboratories, National Institutes of Health, Hamilton, Montana

Grant Year: 2024

Joaquín Castilla, PhD

Grant Title:
Exploring the efficacy of dominant negative protein-based gene therapy for different prion diseases: in vivo proof-of-concept study
Location:
Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain

Grant Year: 2024

Dr. Adriano Aguzzi and Davide Caredio

Grant Title:
Investigation of Glycoprotein Nonmetastatic Melanoma protein B (GPNMB) as potential therapeutic target in Prion Diseases

Location:
University of Zurich

Grant Year: 2024