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Mechanisms of Neurodegeneration in Human Prion Diseases and Their Intersection with AD/ADRD

At this conference experts in prion diseases and prion-like neurodegenerative disorders will gather to explore current disease mechanistic, translational, and clinical concepts, and identify potential collaborative synergies.

Human prion disorders, such as Creutzfeldt-Jakob Disease (CJD), are invariably fatal neurodegenerative diseases involving the misfolding, aggregation, and propagation of the cellular prion protein (PrPC). Despite its comparative rarity, understanding mechanisms of neurodegeneration in CJD and other prion diseases will have a large impact on human health, given that overlapping disease mechanisms underlie the pathogenesis of more common neurodegenerative disorders including Alzheimer’s and Parkinson’s Diseases. Indeed, several major advances in our ability to diagnose and classify neurodegenerative diseases stem from concepts that originated in the prion disease research community, including the SYNTap biomarker test for Parkinson’s disease.

While our understanding of prion diseases has increased significantly, many important questions remain unanswered, including: 1) what is the structure of human prions; 2) what are the mechanisms of prion neurotoxicity; 3) what factors control prion formation, propagation, and clearance in the brain; and 4) to what extent do these principles apply to other neurodegenerative disorders such as AD/ADRD? The conference will probe those questions and facilitate dialogue between experts in prion disease pathogenesis and prion-like mechanisms in AD/ADRD that will be of mutual benefit to both fields.

Can’t attend in person? Register to view the conference live stream.

Stanley B. Prusiner, MD, Director, Institute for Neurodegenerative Diseases, University of California, San Francisco Weill Institute for Neurosciences, San Francisco, CA, U.S.A.

Michel Goedert, Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, England

John Collinge, MD, Director, MRC Prion Unit, Institute of Prion Diseases, UC London, London, England

  • Date : November 12, 2024 - November 14, 2024
  • Time : 9:00 am - 3:00 pm (America/New_York)
  • Venue : 5151 Pooks Hill Road Bethesda, Maryland 20814

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