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Roberto Chiesa, PhD

Grant Title: “Nanoparticle-mediated brain delivery of a tetracationic porphyrin with potent anti-prion activities”

Location: Laboratory of Prion Neurobiology, Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy

Grant Year: 2019



About the Researcher:

Dr. Chiesa has identified a porphyrin that has two potentially synergic anti-prion properties: it down-regulates PrPC, thus depleting the substrate for prion formation, and inhibits PrPSc replication in in vitro and ex vivo models. The aims of the project are: 1) to use nanoparticles engineered to cross the blood-brain barrier to efficiently deliver this compound to the brain; and 2) to carry out efficacy tests in prion-infected mice.

Recipient of: