Contributed by: Jeanne Cole
Established in 2015
Grant Title: Assessing efficacy of a PrP-lowering Molecular Gate as a therapeutic for prion disease
Location: Gate Bioscience
Grant Year: 2025
Grant Title:
Validation of a non-invasive diagnostic test for prion diseases using tear fluid
Location:
Dementia Research Unit, Dept. of Neurology in Göttingen, National Reference Center for TSE and German Center for Neuro-degenerative diseases, Germany
Grant Year: 2024
Grant Title:
Exploring the efficacy of dominant negative protein-based gene therapy for different prion diseases: in vivo proof-of-concept study
Location:
Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain
Grant Year: 2024
Grant Title:
Developing Therapeutics for CJD Using Patient-Specific iPSC-Derived Neurons
Location:
National Prion Disease Pathology Surveillance Center, Case Western Reserve University School of Medicine Cleveland, Ohio
Grant Year:
2015
Grant Title:
Human stem cell derived neural models for sCJD prion propagation and drug discovery
Location:
Institute for Neurodegenerative Diseases, University of California, San Francisco
Grant Year:
2016
Grant Title:
Antisense Oligonucleotides to delay or prevent onset of prion disease in mice
Location:
National Institute of Allergy and Infectious Diseases, National Institute of Health
Grant Year:
2016
Grant Title:
Design and Development of Anti-Prions as a Novel Therapeutic Strategy for Prion Disease
Location:
Mitchell Center for Alzheimer’s Disease and Related Brain Disorders, Department of Neurology, University of Texas-Houston Medical School
Grant Year:
2017
Grant Title:
“Highly Synergistic Combination Therapy for Prion Diseases”
Location:
Department of Biochemistry, Boston University School of Medicine
Grant Year:
2018
Grant Title: Assessing long-term stability of cerebrospinal fluid PrP levels in genetic prion disease mutation carriers
Location: Professor of Neurology, Harvard Medical School; and Translational Neurology Head of the Interdisciplinary Brain Center, Massachusetts General Hospital
Grant Year: 2019
Grant Title:
Development of a blood and urine prion diagnostic test for human prion diseases using the Real Time QuIC assays
Location:
Department of Biomedical Sciences, University of Cagliari (UniCa), Cagliari, Italy
Grant Year: 2023
Grant Title:
Generation of Humanised STX6 Overexpression Mice to Study Prion Disease Genetic Risk and as a Model for Therapeutic Intervention
Location:
MRC Prion Unit at UCL, Institute of Prion Diseases, London
Grant Year: 2023
Grant Title:
Improving the sensitivity of CSF RT-QuIC in humans by examining cases with indeterminate results
Location:
National Prion Disease Pathology Surveillance Center, Case Western Reserve University, University Hospitals Cleveland Medical Center, Cleveland, OH
Grant Year: 2022
Grant Title:
Optimization of nanoparticle-mediated brain delivery of a tetracationic porphyrin with potent anti-prion activities
Location:
University of Modena and Reggio Emilia, Modena, Italy
Grant Year: 2021
Grant Title:
The RAP approach for effective prevention and treatment of prion diseases
Location:
Case Western Reserve University
Grant Year:
2020