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Rodrigo Morales, PhD

Grant Title:
Development of a high throughput system for screening anti-prion molecules

Location:
University of Texas, Houston, TX

Grant Year: 2022

Hermann Clemens Altmeppen, PhD

Grant Title:
Enzymatic PrP shedding in humans: Biomarker potential and therapeutic target

Location:
Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Grant Year: 2022

Maria Letizia Barreca, PhD

Grant Title:
Blocking the Neurotoxic Activities of Mutant Prion Proteins by a Novel Class of Therapeutic Agents

Location:
Department of Pharmaceutical Sciences (DPS), University of Perugia-Italy

Grant Year: 2022

Marcelo Barria, PhD & Alison Green, PhD

Grant Title:
Assessing the replication properties of prion protein aggregates found in archived formalin-fixed, paraffin embedded appendix tissue collected from the asymptomatic population by the highly sensitive in vitro prion amplification assay.

Location:
National CJD Research & Surveillance Unit, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK

Grant Year: 2022

Joaquín Castilla, PhD

Grant Title: Development and characterization of the fastest animal model able to propagate GSS prions faithfully

Location:
Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain

Grant Year: 2022

Leonardo Cortez, PhD & Valerie Sim, MD, FRCPC

Grant Title:
Prion protein aggregate size distribution drives clinical phenotype

Location:
Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada

Grant Year: 2022

Cathryn Haigh, PhD

Grant Title:
“Regional tropism of sporadic CJD subtypes in human brain organoids”

Location:
Laboratory of Neurological Infections and Immunity (LNII), National Institute of Allergy and Infectious Diseases (NIAID), Division of Intramural Research, Rocky Mountain Laboratories, National Institutes of Health, Hamilton, MT

Grant Year: 2022

Jaime Noguez

Grant Title:
Improving the sensitivity of CSF RT-QuIC in humans by examining cases with indeterminate results

Location:
National Prion Disease Pathology Surveillance Center, Case Western Reserve University, University Hospitals Cleveland Medical Center, Cleveland, OH

Grant Year: 2022

Shashirekha Shetty, PhD

Grant Title:
Examining copy number variants as a possible phenotype modifier in prion disease

Location:
National Prion Disease Pathology Surveillance Center, Case Western Reserve University, University Hospitals, Cleveland, OH

Grant Year: 2022

Zerui Wang, MD, PhD and Katsumi Doh-ura, MD, PhD

Grant Title:
Assessing Prophylactic and Therapeutic Efficacy of a Cellulose Ether Compound TC-5RW on CJD

Location:
Department of Pathology, Case Western Reserve University, Cleveland, Ohio

Grant Year: 2022