The Eugene A. Riedel Memorial Research Grant
Contributed by: Jacqueline Riedel
This grant was established in 2018.
Prion disease, a rare but fatal neurodegenerative disorder, is caused by prion, a prion protein with the wrong shape (PrPSc) that has the ability to induce the normal good prion protein (PrPC) to adapt to the wrong shape (PrPSc) and spread in the brain. However, we still don’t have a clear picture of how PrPSc converts and spreads, largely due to the lack of high-resolution structural information of PrPSc, hence impeding the developments of efficacious therapeutics against these currently incurable diseases. The main goal of this project is to develop methods for large scale production of high-quality human PrPSc for structural studies that will facilitate the structure-based drug design to treat human prion diseases.
My primary research focus has been on studying prion protein (PrP) misfolding associated with prion disease, which represents the prototypical protein misfolding-associated neurodegenerative disorder that affects both human and animals. Our lab has shown that infectious recombinant PrPSc (recPrPSc) can be generated from bacterially expressed non-infectious recombinant PrP (recPrP) in a novel in vitro protein misfolding system containing auxiliary cofactors. Our recent studies have demonstrated that recPrPSc share structural features with native PrPSc, suggesting that recPrPSc is a good resource for structural studies of infectious prions. Lately I have been working on developing the large-scale production system for generating high-quality recPrPSc in large quantity.
Contributed by: Jacqueline Riedel
This grant was established in 2018.
Contributed by: The Highman and Nugent Families
This grant was established in 2020.
Contributed by: David Morris and Family
This grant was established in 2019.
Contributed by: The Hunter Family and Byron Jones
This grant was established in 2019.
Contributed by:
Williams Family
Established in 2021.
Contributed by: Tim Molloy and Family
Established in 2019.
This website was made possible by a generous donation from Cookie Stivison, in memory of her husband Tom Stivison, and a grant from the Centers for Disease Control and Prevention.
