The Strides for CJD Research Grant

Contributed by: The Families of the CJD Foundation

Funds raised by the annual Strides for CJD run/walk have been applied to research grants awarded since 2016.

Research Grants Supported

Zuzana Krejciova, Ph.D.

Grant Title:
Human stem cell derived neural models for sCJD prion propagation and drug discovery

Location:
Institute for Neurodegenerative Diseases, University of California, San Francisco

Grant Year:
2016

Roberto Chiesa, Ph.D.

Grant Title:
A new anti-prion compound that reduces PrPc levels and inhibits PrPsc replication. [Awaiting permission to release from Dr. Chiesa.]

Location:
Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy

Grant Year: 2016

Wen-Quan Zou, M.D., Ph.D.

Grant Title:
Assessing Prions in Sporadic CJD Patients

Location:
National Prion Disease Pathology Surveillance Center, Case Western Reserve University, Cleveland, Ohio

Grant Year:
2017

Gianluigi Zanusso, MD, PhD

Grant Title:
RT-QuIC assay on olfactory brushings in asymptomatic carriers of E200K mutation: An explorative study for establishing when a preventive therapy should be started

Location:
University of Verona, Italy

Grant Year:
2017

Stéphane Haik, M.D., Ph.D.

Grant Title:
Worms: A novel genetic model for therapeutic research in prion disease

Location:
Alzheimer’s and Prion diseases Lab at the Brain & Spine Institute (ICM) of the Salpêtrière Hospital, Sorbonne Université, Paris, France

Grant Year:
2017

Rodrigo Morales, Ph.D.

Grant Title:
“Systematic Evaluation of the Zoonotic Potential of Different CWD Isolates”

Location:
Mitchell Center for Alzheimer’s Disease and Related Brain Disorders, Department of Neurology, University of Texas-Houston Medical School

Grant Year:
2018

Leonardo Cortez, Ph.D.

Grant Title:
“Isolation and Strain-Specific Characterization of Pathogenic CJD Prion Particles”

Location:
Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada

Grant Year:
2018

Dr. Hermann Clemens Altmeppen

Grant Title:
“Investigating the Potential of the Neuroprotective N1 Fragment of the Prion Protein as a New Treatment Against Prion Diseases”

Location:
Institute of Neuropathology, University Medical Center – Eppendorf, Hamburg, Germany

Grant Year:
2018

Dr. Emmanuelle Vire

Grant Title:
Investigating the relevance of blood DNA methylation signals for disease management in CJD

Location:
Medical Research Council (MRC) Prion Unit at University College London

Grant Year: 2019

Dr. Graham S. Jackson

Grant Title: Development of a quantitative, real-time Protein-Misfolding by Cyclic Amplification (PMCA) reaction
Location: Medical Research Council (MRC) Prion Unit at University College London
Grant Year: 2019

Simote Totauhelotu Foliaki, PhD

Grant Title:
Cerebral neuronal dysfunction associated with human prion diseases

Location:
National Institute of Allergy and Infectious Diseases, NIH

Grant Year: 2019

Candace Mathiason, PhD

Grant Title:
“Use of Blood-borne Prion Amplification Assays for the Detection of Human Prion Diseases and Biomarker Assessment”

Location:
Prion Research Center, Colorado State University

Grant Year:
2020

Robert C.C. Mercer, Ph.D.

Grant Title:
The identification of PrPSc interaction partners and the characterization of their role in prion infection and/or propagation

Location:
Instructor, Department of Biochemistry, Boston University School of Medicine

Grant Year: 2023

Qiuye Li, Ph.D.

Grant Title:
“High-resolution structure determination of MM1 and MM2 sCJD prions”

Location:
Department of Physiology and Biophysics, School of Medicine; Case Western Reserve University, Cleveland, OH

Grant Year: 2023

Victoria Lawson, PhD

Grant Title:
Risk of cancer from reduced expression of PrPC-implications for prion disease treatment”

Location:
Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Victoria, Australia

Grant Year: 2023

Dr. Thomas Cunningham and Elizabeth Hill

Grant Title:
Generation of Humanised STX6 Overexpression Mice to Study Prion Disease Genetic Risk and as a Model for Therapeutic Intervention

Location:
MRC Prion Unit at UCL, Institute of Prion Diseases, London

Grant Year: 2023

Joaquín Castilla, PhD

Grant Title: Development and characterization of the fastest animal model able to propagate GSS prions faithfully

Location:
Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain

Grant Year: 2022

Holger Wille, PhD

Grant Title:
Evaluating prion vaccines in transgenic mouse models of familial prion diseases

Location:
University of Alberta, Edmonton, Alberta, Canada

Grant Year: 2021

Valerie Sim, MD, FRCPC

Grant Title:
Strain-specific pathology and spread in prion organotypic slice culture assay infected with different strains of Creutzfeldt-Jakob Disease

Location:
Centre for Prions and Protein Folding Diseases, University of Alberta, Canada

Grant Year: 2021

Simon Mead, PhD

Grant Title:
Genome-wide association study (GWAS) of age at clinical onset in inherited prion disease (genetic CJD)

Location:
University College London (UCL) Institute of Prion Diseases

Grant Year: 2021

Franc Llorens, PhD and Inga Zerr, MD

Grant Title:
Implementation of a blood-based biomarker test for sporadic Creutzfeldt-Jakob in clinical practice”

Location:
The Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Spain and German Center for Neurodegenerative Diseases

Grant Year:
2021

Jason Thomas Duskey and Barbara Ruozi

Grant Title:
Optimization of nanoparticle-mediated brain delivery of a tetracationic porphyrin with potent anti-prion activities

Location:
University of Modena and Reggio Emilia, Modena, Italy

Grant Year: 2021

Stephanie Booth, PhD

Grant Title:
Detection and characterization of rare strains of sporadic Creutzfeldt-Jakob Disease using a suite of novel biological and biochemical tools

Location:
Public Health Agency of Canada and University of Manitoba.

Grant Year: 2021

Alberto Bizzi, MD

Grant Title:
Early diagnosis of CJD from in vivo MRI using the trajectories of prion lesion propagation

Location:
Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy

Grant Year: 2021

Emiliano Biasini, PhD

Grant Title:
Pharmacological Degraders for the Cellular Prion Protein

Location:
University of Trento, Italy

Grant Year:
2021

Fei Wang, PhD

Grant Title:
Generating Recombinant Human Prions in Large Scale for Structural Studies

Location:
The Mitchell Center for Alzheimer’s Disease and Related Brain Disorders; The University of Texas Health Science Center at Houston

Grant Year: 2020

Sonia Vallabh

Grant Title:
Assessing efficacy of zinc-finger repressors of prion protein as a therapeutic for prion disease

Location:
Broad Institute of MIT and Harvard

Grant Year: 2020

Rodrigo Morales, PhD

Grant Title:
Exploring the zoonotic potential of porcine-derived materials from animals exposed to infectious prions

Location:
Department of Neurology, The University of Texas Health Science Center at Houston

Grant Year: 2020

Qingzhong Kong, PhD

Grant Title:
The RAP approach for effective prevention and treatment of prion diseases

Location:
Case Western Reserve University

Grant Year:
2020

Natalia do Carmo Ferreira de Araujo

Grant Title:
Evaluation of new anti-prion drugs: from drug design to therapeutic efficacy against human prions in vitro, ex-vivo and in vivo

Location:
Rocky Mountain Laboratories, NIH/NIAID

Grant Year: 2020