Jiyan Ma, PhD

Location: 

Professor, Center for Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI

Grant Year: 

2019


This study tests the possibility of using a specific version of anti-prion antibody (a nanobody) to block prion propagation and thereby to stop the progression of prion disease.  The nanobody is a promising therapeutic agent against prion disease, binds to PrPc with high affinity, abolishes prion infection in cells, inhibits prion propagation by PMCA, and shows no neurotoxicity in brain cell cultures.

Dr. Ma is the recipient of: