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Jiyan Ma, PhD

Grant Title: Determining the therapeutic potential of anti-PrP nanobody

Location: Professor, Center for Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI

Grant Year: 2019



This study tests the possibility of using a specific version of anti-prion antibody (a nanobody) to block prion propagation and thereby to stop the progression of prion disease.  The nanobody is a promising therapeutic agent against prion disease, binds to PrPc with high affinity, abolishes prion infection in cells, inhibits prion propagation by PMCA, and shows no neurotoxicity in brain cell cultures.

Recipient of:

The CJD Foundation Grant

Contributed by: The Families of the CJD Foundation

Funds donated by supporters of the CJD Foundation have been applied to research grants awarded since 2009.