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Emiliano Biasini, PhD

Grant Title: Pharmacological Degraders for the Cellular Prion Protein

Location: University of Trento, Italy

Grant Year: 2021



Prion diseases are rare neurodegenerative conditions affecting humans and other mammals. These pathologies can be transmitted via genetic or infectious routes and are responsible for the epidemics of bovine spongiform encephalopathy, also known as mad cow disease, which mainly affected Europe in the late 1990s. Prion diseases are caused by the conversion of a normal protein, called the cellular prion protein (abbreviated PrP), into an aberrant form, called the scrapie prion protein (abbreviated PrPSc). Once formed, PrPSc behaves like an infectious agent (prion), propagating by inducing the conversion of additional PrP molecules, accumulating in large aggregates in brain tissues, and ultimately damaging the nervous system. While no cures are currently available for these disorders, recent evidence has provided strong support for the idea of lowering the expression of the normal form of PrP to treat prion diseases. We have recently developed a new technology, called PPI-FIT, for identifying drugs capable of selectively lowering the expression of target proteins. Thanks to PPI-FIT, we have identified a promising molecule able to reduce PrP levels and block prion replication in cells. However, the compound must be further developed to improve its pharmacological properties and make it safely administrable to humans. The project intends to directly pursue these tasks, with the ultimate goal to define a novel pharmacological option to test in prion disease patients.

About the Researcher:

Emiliano Biasini, PhD
Dulbecco Telethon Laboratory of Prions and Amyloids, Department of Cellular, Computational & Integrative Biology (CIBIO), University of Trento, Italy

Dr. Biasini is currently an Associate professor at the University of Trento. He devoted his entire career to studying prions and prion diseases. His laboratory is trying to explore new experimental avenues to identify treatments for prion diseases.

Author of 55 papers in international scientific journals and inventor of 3 patents about therapeutics and drug-discovery approaches for neurodegenerative diseases. Co-founder and scientific advisor at Sibylla Biotech (

Career milestones:

  • 1999. Degree in Biological Sciences from University of RomaTre, in Rome (Italy)

  • 2004. Specialization in Pharmacology from the Mario Negri Institute in Milan (Italy)

  • 2005. PhD in Applied Genetics from University of La Sapienza in Rome (Italy)

  • 2005-2013. Post-doc at Washington University and Boston University (USA)

  • 2015-to date. Associate Professor at the Laboratory of Prions & Amyloids, Department CIBIO, University of Trento

  • 2017-to date. Co-founder and scientific advisor at Sibylla Biotech

  • 2020-to date. Affiliated to the Interdepartmental Center for Medical Sciences (CISMed), University of Trento

Recipient of:

The Strides for CJD Research Grant

Contributed by: The Families of the CJD Foundation

Funds raised by the annual Strides for CJD run/walk have been applied to research grants awarded since 2016.

The CJD Foundation Grant

Contributed by: The Families of the CJD Foundation

Funds donated by supporters of the CJD Foundation have been applied to research grants awarded since 2009.