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The CJD Foundation Grant

Contributed by: The Families of the CJD Foundation

Funds donated by supporters of the CJD Foundation have been applied to research grants awarded since 2009.

Research Grants Supported

Gianluigi Zanusso, MD, PhD

Grant Title: Multi-center assessment of olfactory swab procedure performed by non-otolaryngologists for improving and simplifying human prion disease diagnosis

Location: Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy

Grant Year: 2025

Wen-Quan Zou, M.D., Ph.D.

Grant Title:
“Assessing long-term stability of The CJD Foundations 2009 Research Grant Renewal: Comparative Study of Prions Associated with Iatrogenic and Sporadic Creutzfeldt-Jakob Disease: An Update

Location:
Department of Pathology, Case Western Reserve University; Associate Director of National Prion Disease Pathology Surveillance Center, Cleveland, Ohio

Grant Year:
2009

Qingzhong Kong, Ph.D.

Grant Title:
Etiology of Sporadic CJD: Somatic Mutations of the Human Prion Protein Gene in Brain Cells

Location:
The National Prion Disease Pathology Surveillance Center, Cleveland, Ohio

Grant Year:
2009

Dr. Hermann Clemens Altmeppen

Grant Title:
Targeting the endogenous proteolytic processing of PrPc as a therapeutic strategy against prion diseases

Location:
Institute of Neuropathology, University Medical Center Eppendorf

Grant Year:
2016

Rodrigo Morales, Ph.D.

Grant Title:
“Systematic Evaluation of the Zoonotic Potential of Different CWD Isolates”

Location:
Mitchell Center for Alzheimer’s Disease and Related Brain Disorders, Department of Neurology, University of Texas-Houston Medical School

Grant Year:
2018

Jiyan Ma, PhD

Grant Title:
Determining the therapeutic potential of anti-PrP nanobody

Location: Professor, Center for Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI

Grant Year: 2019

Simote Totauhelotu Foliaki, PhD

Grant Title:
Cerebral neuronal dysfunction associated with human prion diseases

Location:
National Institute of Allergy and Infectious Diseases, NIH

Grant Year: 2019

Candace Mathiason, PhD

Grant Title:
“Use of Blood-borne Prion Amplification Assays for the Detection of Human Prion Diseases and Biomarker Assessment”

Location:
Prion Research Center, Colorado State University

Grant Year:
2020

Robert C.C. Mercer, Ph.D.

Grant Title:
The identification of PrPSc interaction partners and the characterization of their role in prion infection and/or propagation

Location:
Instructor, Department of Biochemistry, Boston University School of Medicine, Boston, MA

Grant Year: 2023

Qiuye Li, Ph.D.

Grant Title:
“High-resolution structure determination of MM1 and MM2 sCJD prions”

Location:
Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH

Grant Year: 2023

Victoria Lawson, PhD

Grant Title:
Risk of cancer from reduced expression of PrPC-implications for prion disease treatment”

Location:
Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Victoria, Australia

Grant Year: 2023

Jason C. Bartz, PhD and Qi Yuan, PhD

Grant Title:
Detection of residual prions from decontaminated medical and laboratory surfaces

Location:
School of Medicine, Creighton University, Omaha, NE

Grant Year: 2023

Jaime Noguez

Grant Title:
Improving the sensitivity of CSF RT-QuIC in humans by examining cases with indeterminate results

Location:
National Prion Disease Pathology Surveillance Center, Case Western Reserve University, University Hospitals Cleveland Medical Center, Cleveland, OH

Grant Year: 2022

Holger Wille, PhD

Grant Title:
Evaluating prion vaccines in transgenic mouse models of familial prion diseases

Location:
University of Alberta, Edmonton, Alberta, Canada

Grant Year: 2021

Simon Mead, PhD

Grant Title:
Genome-wide association study (GWAS) of age at clinical onset in inherited prion disease (genetic CJD)

Location:
University College London (UCL) Institute of Prion Diseases

Grant Year: 2021

Franc Llorens, PhD and Inga Zerr, MD

Grant Title:
Implementation of a blood-based biomarker test for sporadic Creutzfeldt-Jakob in clinical practice”

Location:
The Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Spain and German Center for Neurodegenerative Diseases

Grant Year:
2021

Stephanie Booth, PhD

Grant Title:
Detection and characterization of rare strains of sporadic Creutzfeldt-Jakob Disease using a suite of novel biological and biochemical tools

Location:
Public Health Agency of Canada and University of Manitoba.

Grant Year: 2021

Alberto Bizzi, MD

Grant Title:
Early diagnosis of CJD from in vivo MRI using the trajectories of prion lesion propagation

Location:
Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy

Grant Year: 2021

Emiliano Biasini, PhD

Grant Title:
Pharmacological Degraders for the Cellular Prion Protein

Location:
University of Trento, Italy

Grant Year:
2021

Fei Wang, PhD

Grant Title:
Generating Recombinant Human Prions in Large Scale for Structural Studies

Location:
The Mitchell Center for Alzheimer’s Disease and Related Brain Disorders; The University of Texas Health Science Center at Houston

Grant Year: 2020

Sonia Vallabh

Grant Title:
Assessing efficacy of zinc-finger repressors of prion protein as a therapeutic for prion disease

Location:
Broad Institute of MIT and Harvard

Grant Year: 2020

Qingzhong Kong, PhD

Grant Title:
The RAP approach for effective prevention and treatment of prion diseases

Location:
Case Western Reserve University

Grant Year:
2020

Natalia do Carmo Ferreira de Araujo

Grant Title:
Evaluation of new anti-prion drugs: from drug design to therapeutic efficacy against human prions in vitro, ex-vivo and in vivo

Location:
Rocky Mountain Laboratories, NIH/NIAID

Grant Year: 2020