Iatrogenic and occupational prion transmission of human prion diseases has occurred. While methods of prion surface decontamination exist, validating that decontamination procedure are successful is currently not possible. This proposal will utilize an innovative surface-recovery method combined with real-time quaking-induced conversion (RT-QuIC) to detect residual prions from a variety of surfaces. The results of these studies will allow for surveying of residual prions in laboratory and clinical settings.
Jason C. Bartz, PhD and Qi Yuan, PhD
School of Medicine, Creighton University, Omaha, NE
Detection of residual prions from decontaminated medical and laboratory surfaces
Qi Yuan, PhD is a Research Assistant Professor in the Department of Medical Microbiology and Immunology at the Creighton University School of Medicine. Dr. Yuan earned a Ph.D. in Civil engineering at the University of Nebraska, Lincoln. Dr. Yuan investigates environmental prion fate and has identified important factors affecting its persistence and has developed a novel methodology to detect surface prions that has utility in environmental, laboratory, and medical settings.
Jason C. Bartz, PhD is Professor and Chair in the Department of Medical Microbiology and Immunology at the Creighton University School of Medicine. Dr. Bartz earned a Ph.D. at the University of Wisconsin, Madison. Dr. Bartz investigates interspecies transmission, pathogenesis, and the biology of prion strains whose work has sought to understand how a protein-only infectious agent can perform complex biological tasks.
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Funds donated by supporters of the CJD Foundation have been applied to research grants awarded since 2009.
Contributed by: Sandra (Cookie) Stivison
Established in 2015.
Contributed by: The Families of the CJD Foundation
Funds raised by the annual Strides for CJD run/walk have been applied to research grants awarded since 2016.
Contributed by: Jim Black and Family
Established in 2022.
Contributed by: Jan Wolter, Family, and Friends
Established in 2023.
This website was made possible by a generous donation from Cookie Stivison, in memory of her husband Tom Stivison, and a grant from the Centers for Disease Control and Prevention.
