Using a new human brain tissue model, this study intends to understand the ways in which brain electrical signaling becomes disrupted in individuals who are pre-disposed to familial prion diseases and when nerve cells are subjected to toxic human prions. The investigators will then use the new model to determine whether putative anti-prion compounds can reverse or prevent prion-induced changes in brain electrical signaling in human brain cells. Ultimately, the investigators aim to identify new pathway targets for therapeutic intervention in human disease.
Contributed by: Patrick Gleeson and Kelly Gleeson-Piacentini
This grant was established in 2019.
Contributed by: Jacqueline Riedel
This grant was established in 2018.
Contributed by: Kathy Baxley and Family
Established in 2018.
Contributed by: The Families of the CJD Foundation
Funds raised by the annual Strides for CJD run/walk have been applied to research grants awarded since 2016.
Contributed by: The Families of the CJD Foundation
Funds donated by supporters of the CJD Foundation have been applied to research grants awarded since 2009.
This website was made possible by a generous donation from Cookie Stivison, in memory of her husband Tom Stivison, and a grant from the Centers for Disease Control and Prevention.
