Grant Title: Refined transgenetic approaches to investigate selective adaptation of human prions during intracranial and peripheral transmissions
Location: Prion Research Center, Colorado State University
Grant Year: 2025
Grant Title: Investigating prion protein seeding activity in non-prion disease dementia
Location: Department of Medicine and Surgery, University Kore of Enna, Italy; Adjunct Assistant Professor in the Department of Pathology, at Case Western Reserve University (CWRU); Associate Director at National Prion Disease Pathology Surveillance Center (NPDPSC), Cleveland, OH
Grant Year: 2025
Grant Title: Characterization of synaptic abnormalities in iPSC-derived neurons from E200K carriers
Location: Boston University Chobanian & Avedisian School of Medicine
Grant Year: 2025
Grant Title: Assessing retinal function as a potential early biomarker for Creutzfeldt-Jakob Disease (CJD)
Location: Department of Optometry and Vision Sciences, The University of Melbourne
Grant Year: 2025
Grant Title: Engineering human cells to propagate fluorescent prions for live monitoring of prion infection and high-resolution in situ prion structure determination
Location: Imperial College London, Faculty of Medicine, Department of Infectious Disease,
Synthetic and Structural Biology Section
Grant Year: 2025
Grant Title: Assessing efficacy of a PrP-lowering Molecular Gate as a therapeutic for prion disease
Location: Gate Bioscience
Grant Year: 2025
Grant Title: Higher-resolution visualization of prion fibrils in neurons and extracellular vesicles using state-of-the-art Cryo-TEM and FIB-SEM imaging
Location: Rocky Mountain Laboratories, NIAID, NIH
Grant Year: 2025
Grant Title: Engineered biosensors for improved prion detection
Location: Tanz Centre for Research in Neurodegenerative Diseases and Department of Biochemistry, University of Toronto
Grant Year: 2025
Grant Title: Multi-center assessment of olfactory swab procedure performed by non-otolaryngologists for improving and simplifying human prion disease diagnosis
Location: Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy
Grant Year: 2025
Grant Title:
Investigation of Glycoprotein Nonmetastatic Melanoma protein B (GPNMB) as potential therapeutic target in Prion Diseases
Location:
University of Zurich
Grant Year: 2024
Grant Title:
Exploring the efficacy of dominant negative protein-based gene therapy for different prion diseases: in vivo proof-of-concept study
Location:
Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain
Grant Year: 2024
Grant Title:
Generating cerebral organoids from donors with sporadic Creutzfeldt-Jakob Disease
Location:
Postdoctoral Research Fellow at Rocky Mountain Laboratories, National Institutes of Health, Hamilton, Montana
Grant Year: 2024
Grant Title:
Development of ADAM8-based Gene Therapy for CJD
Location:
NPDPSC, Case Western Reserve University
Grant Year: 2024
Grant Title:
Understanding the molecular mechanism of spontaneous prion emergence in knock-in mouse models
Location:
Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto
Grant Year: 2024
Grant Title:
Bridging the pre-clinical gap for a small brain-penetrant molecule that reduces PrPC levels
Location:
Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto
Grant Year: 2024
Grant Title:
Validation of a non-invasive diagnostic test for prion diseases using tear fluid
Location:
Dementia Research Unit, Dept. of Neurology in Göttingen, National Reference Center for TSE and German Center for Neuro-degenerative diseases, Germany
Grant Year: 2024
Grant Title:
Detection of residual prions from decontaminated medical and laboratory surfaces
Location:
School of Medicine, Creighton University, Omaha, NE
Grant Year: 2023
Grant Title:
Investigating prion protein seeding activity in Alzheimer’s disease and chronic traumatic encephalopathy
Location:
Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH
Grant Year: 2023
Grant Title:
Generation of Humanised STX6 Overexpression Mice to Study Prion Disease Genetic Risk and as a Model for Therapeutic Intervention
Location:
MRC Prion Unit at UCL, Institute of Prion Diseases, London
Grant Year: 2023
Grant Title:
Elucidating the factors required for propagating human CJD prions
Location:
MRC Prion at UCL, Institute of Prion Diseases, London
Grant Year: 2023
Grant Title:
Risk of cancer from reduced expression of PrPC-implications for prion disease treatment”
Location:
Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Victoria, Australia
Grant Year: 2023
Grant Title:
“High-resolution structure determination of MM1 and MM2 sCJD prions”
Location:
Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH
Grant Year: 2023
Grant Title:
The identification of PrPSc interaction partners and the characterization of their role in prion infection and/or propagation
Location:
Instructor, Department of Biochemistry, Boston University School of Medicine, Boston, MA
Grant Year: 2023
Grant Title:
Contribution of oligomeric prion populations to phenotypic heterogeneity in variably protease-sensitive prionopathy (VPSPr) versus silent prions
Location:
Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada
Grant Year: 2023
Grant Title:
Development of a blood and urine prion diagnostic test for human prion diseases using the Real Time QuIC assays
Location:
Department of Biomedical Sciences, University of Cagliari (UniCa), Cagliari, Italy
Grant Year: 2023
Grant Title:
Enzymatic PrP shedding in humans: Biomarker potential and therapeutic target
Location:
Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Grant Year: 2022
Grant Title:
Blocking the Neurotoxic Activities of Mutant Prion Proteins by a Novel Class of Therapeutic Agents
Location:
Department of Pharmaceutical Sciences (DPS), University of Perugia-Italy
Grant Year: 2022
Grant Title:
Assessing the replication properties of prion protein aggregates found in archived formalin-fixed, paraffin embedded appendix tissue collected from the asymptomatic population by the highly sensitive in vitro prion amplification assay.
Location:
National CJD Research & Surveillance Unit, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK
Grant Year: 2022
Grant Title: Development and characterization of the fastest animal model able to propagate GSS prions faithfully
Location:
Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain
Grant Year: 2022
Grant Title:
Prion protein aggregate size distribution drives clinical phenotype
Location:
Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada
Grant Year: 2022
Grant Title:
“Regional tropism of sporadic CJD subtypes in human brain organoids”
Location:
Laboratory of Neurological Infections and Immunity (LNII), National Institute of Allergy and Infectious Diseases (NIAID), Division of Intramural Research, Rocky Mountain Laboratories, National Institutes of Health, Hamilton, MT
Grant Year: 2022
Grant Title:
Development of a high throughput system for screening anti-prion molecules
Location:
University of Texas, Houston, TX
Grant Year: 2022
Grant Title:
Improving the sensitivity of CSF RT-QuIC in humans by examining cases with indeterminate results
Location:
National Prion Disease Pathology Surveillance Center, Case Western Reserve University, University Hospitals Cleveland Medical Center, Cleveland, OH
Grant Year: 2022
Grant Title:
Examining copy number variants as a possible phenotype modifier in prion disease
Location:
National Prion Disease Pathology Surveillance Center, Case Western Reserve University, University Hospitals, Cleveland, OH
Grant Year: 2022
Grant Title:
Assessing Prophylactic and Therapeutic Efficacy of a Cellulose Ether Compound TC-5RW on CJD
Location:
Department of Pathology, Case Western Reserve University, Cleveland, Ohio
Grant Year: 2022
Grant Title:
Pharmacological Degraders for the Cellular Prion Protein
Location:
University of Trento, Italy
Grant Year:
2021
Grant Title:
Early diagnosis of CJD from in vivo MRI using the trajectories of prion lesion propagation
Location:
Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy
Grant Year: 2021
Grant Title:
Detection and characterization of rare strains of sporadic Creutzfeldt-Jakob Disease using a suite of novel biological and biochemical tools
Location:
Public Health Agency of Canada and University of Manitoba.
Grant Year: 2021
Grant Title:
Optimization of nanoparticle-mediated brain delivery of a tetracationic porphyrin with potent anti-prion activities
Location:
University of Modena and Reggio Emilia, Modena, Italy
Grant Year: 2021
Grant Title:
Implementation of a blood-based biomarker test for sporadic Creutzfeldt-Jakob in clinical practice”
Location:
The Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Spain and German Center for Neurodegenerative Diseases
Grant Year:
2021
Grant Title:
Genome-wide association study (GWAS) of age at clinical onset in inherited prion disease (genetic CJD)
Location:
University College London (UCL) Institute of Prion Diseases
Grant Year: 2021
Grant Title:
Strain-specific pathology and spread in prion organotypic slice culture assay infected with different strains of Creutzfeldt-Jakob Disease
Location:
Centre for Prions and Protein Folding Diseases, University of Alberta, Canada
Grant Year: 2021
Grant Title:
Evaluating passive immunotherapy in prion-infected transgenic mice expressing human PrP
Location:
University of Alberta, Edmonton, Alberta, Canada
Grant Year: 2021
Grant Title:
Evaluation of new anti-prion drugs: from drug design to therapeutic efficacy against human prions in vitro, ex-vivo and in vivo
Location:
Rocky Mountain Laboratories, NIH/NIAID
Grant Year: 2020
Grant Title:
The RAP approach for effective prevention and treatment of prion diseases
Location:
Case Western Reserve University
Grant Year:
2020
Grant Title:
“Use of Blood-borne Prion Amplification Assays for the Detection of Human Prion Diseases and Biomarker Assessment”
Location:
Prion Research Center, Colorado State University
Grant Year:
2020
Grant Title:
Exploring the zoonotic potential of porcine-derived materials from animals exposed to infectious prions
Location:
Department of Neurology, The University of Texas Health Science Center at Houston
Grant Year: 2020
Grant Title:
Investigating the influence of CYP4X1 gene on age at onset of CJD as potential preventive therapeutic approach
Location:
Istituto Superiore di Sanità, Dept. of Neuroscience, Rome
Grant Year: 2020
Grant Title:
The Contribution of Rare Variant and Copy-Number Variation to Risk of Sporadic CJD and Pleiotropy with Other Neurodegenerative Diseases
Location:
Washington University School of Medicine
Grant Year: 2020
Grant Title:
Assessing efficacy of zinc-finger repressors of prion protein as a therapeutic for prion disease
Location:
Broad Institute of MIT and Harvard
Grant Year: 2020
Grant Title:
Generating Recombinant Human Prions in Large Scale for Structural Studies
Location:
The Mitchell Center for Alzheimer’s Disease and Related Brain Disorders; The University of Texas Health Science Center at Houston
Grant Year: 2020
Grant Title:
Evaluating prion vaccines in transgenic mouse models of familial prion diseases
Location:
University of Alberta, Edmonton, Alberta, Canada
Grant Year: 2020
Grant Title: Assessing long-term stability of cerebrospinal fluid PrP levels in genetic prion disease mutation carriers
Location: Professor of Neurology, Harvard Medical School; and Translational Neurology Head of the Interdisciplinary Brain Center, Massachusetts General Hospital
Grant Year: 2019
Grant Title:
“Nanoparticle-mediated brain delivery of a tetracationic porphyrin with potent anti-prion activities”
Location:
Laboratory of Prion Neurobiology, Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
Grant Year: 2019
Grant Title:
Cerebral neuronal dysfunction associated with human prion diseases
Location:
National Institute of Allergy and Infectious Diseases, NIH
Grant Year: 2019
Grant Title: Development of a quantitative, real-time Protein-Misfolding by Cyclic Amplification (PMCA) reaction
Location: Medical Research Council (MRC) Prion Unit at University College London
Grant Year: 2019
Grant Title:
Determining the therapeutic potential of anti-PrP nanobody
Location: Professor, Center for Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI
Grant Year: 2019
Grant Title:
Modeling Creutzfeldt-Jakob Disease Using Human iPSC-derived Neurons
Location:
Center for Regenerative Medicine, Boston University School of Medicine
Grant Year: 2019
Grant Title:
Investigating the relevance of blood DNA methylation signals for disease management in CJD
Location:
Medical Research Council (MRC) Prion Unit at University College London
Grant Year: 2019
Grant Title:
“Investigating the Potential of the Neuroprotective N1 Fragment of the Prion Protein as a New Treatment Against Prion Diseases”
Location:
Institute of Neuropathology, University Medical Center – Eppendorf, Hamburg, Germany
Grant Year:
2018
Grant Title:
“Isolation and Strain-Specific Characterization of Pathogenic CJD Prion Particles”
Location:
Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada
Grant Year:
2018
Grant Title:
“Highly Synergistic Combination Therapy for Prion Diseases”
Location:
Department of Biochemistry, Boston University School of Medicine
Grant Year:
2018
Grant Title:
“Investigation of Prion Inactivation by Reactive Oxygen Species in Vivo”
Location:
Rocky Mountain Laboratories, Montana
Grant Year:
2018
Grant Title:
“Innovative Human 3D Neural Network Model for the Efficient Propagation of Human Prions”
Location:
Institute for Regenerative Medicine and Biotherapy, University of Montpellier, France
Grant Year:
2018
Grant Title:
“Systematic Evaluation of the Zoonotic Potential of Different CWD Isolates”
Location:
Mitchell Center for Alzheimer’s Disease and Related Brain Disorders, Department of Neurology, University of Texas-Houston Medical School
Grant Year:
2018
Grant Title:
Worms: A novel genetic model for therapeutic research in prion disease
Location:
Alzheimer’s and Prion diseases Lab at the Brain & Spine Institute (ICM) of the Salpêtrière Hospital, Sorbonne Université, Paris, France
Grant Year:
2017
Grant Title:
Design and Development of Anti-Prions as a Novel Therapeutic Strategy for Prion Disease
Location:
Mitchell Center for Alzheimer’s Disease and Related Brain Disorders, Department of Neurology, University of Texas-Houston Medical School
Grant Year:
2017
Grant Title:
RT-QuIC assay on olfactory brushings in asymptomatic carriers of E200K mutation: An explorative study for establishing when a preventive therapy should be started
Location:
University of Verona, Italy
Grant Year:
2017
Grant Title:
Assessing Prions in Sporadic CJD Patients
Location:
National Prion Disease Pathology Surveillance Center, Case Western Reserve University, Cleveland, Ohio
Grant Year:
2017
Grant Title:
Targeting the endogenous proteolytic processing of PrPc as a therapeutic strategy against prion diseases
Location:
Institute of Neuropathology, University Medical Center Eppendorf
Grant Year:
2016
Grant Title:
Antisense Oligonucleotides to delay or prevent onset of prion disease in mice
Location:
National Institute of Allergy and Infectious Diseases, National Institute of Health
Grant Year:
2016
Grant Title:
A new anti-prion compound that reduces PrPc levels and inhibits PrPsc replication. [Awaiting permission to release from Dr. Chiesa.]
Location:
Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
Grant Year: 2016
Grant Title:
Human stem cell derived neural models for sCJD prion propagation and drug discovery
Location:
Institute for Neurodegenerative Diseases, University of California, San Francisco
Grant Year:
2016
Grant Title:
Combination therapies for human prion disease
Location:
Department of Medicine, University of Alberta
Grant Year:
2016
Grant Title:
Pharmacological Chaperones for the Cellular Prion Protein
Location:
Center for Integrative Biology (CIBIO) at the University of Trento, Italy
Grant Year:
2015
Grant Title:
Human Mini-Brains as a New Platform to Identify and Validate Pharmaceutical Compounds for the Treatment of CJD
Location:
CEA/DSV/iMETI/SEPIA (Institute for Emerging Illnesses and Innovative Therapies, Department of Prion and Atypical Infections Research), Fontenay-Aux-Roses, France
Grant Year:
2015
Grant Title:
The Role of Cellular Chaperones and the Unfolded Protein Response in Gerstmann-Sträussler-Scheinker Syndrome
Location:
Prion Research Center, Colorado State University
Grant Year:
2015
Grant Title:
Mechanisms of Selective Neuronal Vulnerability in Human Prion Disease
Location:
University of California, San Diego
Grant Year:
2015
Grant Title:
Developing Therapeutics for CJD Using Patient-Specific iPSC-Derived Neurons
Location:
National Prion Disease Pathology Surveillance Center, Case Western Reserve University School of Medicine Cleveland, Ohio
Grant Year:
2015
Grant Title:
Development of an Anti-Mortem and Pre-Symptomatic Diagnostic Test for vCJD and Genetic Human Prion Diseases Using Real Time QuIC
Location:
Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, Monserrato (CA) — Italy
Grant Year:
2012
Grant Title:
In Vitro and In Vivo Modeling of Gerstmann-Sträussler-Scheinker Syndrome (GSS) With Spontaneously Generated Human Recombinant PrPres Harboring the P102L Substitution (P102L-rPrPres)
Location:
American Red Cross, Scientific Affairs, Rockville, Maryland
Grant Year:
2012
Grant Title:
Propagation of CJD Prions in Cultured Cells Expressing Bank Vole PrP
Location:
Institute for Neurodegenerative Diseases, University of California, San Francisco
Grant Year:
2012
Grant Title:
Probing CJD and GSS by Generating Patient-Derived Induced Pluripotent Stem Cells (iPSCs)
Location:
National Prion Disease Pathology Surveillance Center, Case Western Reserve University School of Medicine, Cleveland, Ohio
Grant Year:
2012
Grant Title:
Targeting the Functional Activity of PrPc as a Novel Strategy for Drug Discovery in Prion Diseases
Location:
Harris Laboratory, Boston University, Boston, Massachusetts
Grant Year:
2011
Grant Title:
Developing a Prion Susceptible Human Neuronal Cell Line Based on Reprogramming Fibroblasts from CJD Affected Patients
Location:
Prion Lab, Proteomic Unit, CIC bioGune, Bizkaia, Spain
Grant Year:
2011
Grant Title:
Yeast Model for Studying Heritable Mammalian Prion Diseases in Mammals
Location:
School of Biology, Georgia Institute of Technology, Atlanta, Georgia
Grant Year:
2011
Grant Title:
Etiology of Sporadic CJD: Somatic Mutations of the Human Prion Protein Gene in Brain Cells
Location:
The National Prion Disease Pathology Surveillance Center, Cleveland, Ohio
Grant Year:
2009
Grant Title:
Adult Neurogenesis in Prion Diseases: A New Lead for Therapeutics?
Location:
Department of Molecular and Cellular Pathologies, Institut de Genetique Humaine, Montpellier, France
Grant Year:
2009
Grant Title:
Pentosan Polysulphate: A Friendly Delivery System for Therapy in Prion Diseases
Location:
Clinical, Diagnosis and Therapy of Neurodegenerative Disorders Unit, Department of Cell Biology and Neurosciences, Instituto Superiore di Sanita, Rome, Italy
Grant Year:
2009
Grant Title:
Analyses of the Protein Tau to Help Determine Whether the Newly Discovered Protease-Sensitive Prionopathy is the Sporadic Form of Gerstmann-Sträussler-Scheinker Disease (GSS)
Location:
The National Prion Disease Pathology Surveillance Center, Cleveland, Ohio
Grant Year:
2009
Grant Title:
“Assessing long-term stability of The CJD Foundations 2009 Research Grant Renewal: Comparative Study of Prions Associated with Iatrogenic and Sporadic Creutzfeldt-Jakob Disease: An Update
Location:
Department of Pathology, Case Western Reserve University; Associate Director of National Prion Disease Pathology Surveillance Center, Cleveland, Ohio
Grant Year:
2009
Grant Title:
Searching for Custom Dominant Negative PrPs by In Vitro Prion Replication Studies
Location:
Prion Lab, Proteomic Unit, CIC bioGune, Bizkaia, Spain
Grant Year:
2008
Grant Title:
Studies of Immune Responses to Prion Protein (PrP) During Prion Infection: Role of Regulatory T cells
Location:
Institut National de la Santé et de la Recherche Médicale, Paris, France
Grant Year:
2008
Grant Title:
Comparative Study of Prion Strains Associated with Iatrogenic and Sporadic Creutzfeldt-Jakob Disease
Location:
Case Western Reserve University, Cleveland, Ohio, Recipient of the first CJD Foundation Human Research Grant, Cleveland, Ohio
Grant Year:
2006